Research Scientist (m/f/d)
Coordinator of in vivo Disease Models (Veterinarian / Physician / Biologist)
Heart Diseases are the leading cause of death and represent one of the major medical challenges of our time. The prevalence of acute and chronic heart failure with reduced as well as preserved ejection fraction is worldwide on its rise. The Institute for Experimental Cardiology studies the molecular basis of different forms of cardiac diseases and is embedded in the Collaborative Research Center 1550, the Helmholtz Institute for Translational AngioCardioScience (HI-TAC), and the German Center for Cardiovascular Research (DZHK), providing an ideal infrastructure for innovative translational research.
We are seeking an experienced and highly motivated staff scientist to join our team. You will be responsible for the scientific coordination of our small animal in vivo model core. Your tasks include administration and supervision of a team of well-trained specialized technicians, hands-on performance and further development of microsurgery and phenotyping techniques, and coordination as well planning of genetic mouse lines.
The ideal candidate should have profound experience and deep knowledge in small animal disease models, small animal surgery, generation of mouse genetic models and cardiovascular phenotyping techniques.
The institute has long lasting experience in preclinical in vivo models of cardiovascular diseases and genetic mouse models. In our small animal model and phenotyping core we have established various genetic, pharmacological and surgical small animal models to study mechanisms of heart diseases. We have profound expertise in generating genetic mouse lines and applying CRISPR/Cas9 based gene editing and gene therapy techniques to study the function of specific genes and develop translational approaches. The person joining will be part of an established group of experienced personnel that applies highly standardized procedures and all modern state-of-the-art technologies for comprehensive cardiovascular preclinical in vivo research (e.g. mouse microsurgery platforms, VisualSonics Vevo Echocardiography, DSI PhysioTel Telemetry; acquisition of a PET/MRI system is planned).
- Job-ID: V000014324
- Field of application: Institut für Experimentelle Kardiologie
- Location: Heidelberg
- Job Category: Science and teaching
- Working hours: full-time
- Published: 04.06.2025
- Limitation: Temporary (24 Month, extension is sought)
- Contract: TV-L
Your tasks
- Scientific and organizational coordination of our in-house disease modelling core
- Management, supervision and training of specialized technicians
- Performance, development, implementation and standardization of new small animal surgery and phenotyping methods with high quality standards
- Generation and management of genetic mouse lines (experimental planning, organization of breeding, ensuring of proper husbandry practices)
- Planning and organization of preclinical and translational in vivo studies
- Communication with authorities and academic and industrial collaborators
Your Profile
- You hold a University Degree (or equivalent) in veterinary, biology or medical sciences
- You are experienced in animal surgical and phenotyping techniques (in particular cardiac surgery and imaging)
- You value animal welfare, are familiar with the 3R principles and act accordingly
- You have experience with genetic small animal models and understanding of genetic techniques such as the Cre-LoxP system and CRISPR/Cas9 technology
- You have experience in coordinating scientific research projects and regulatory affairs related to small animal models (mainly mouse models)
- You have an independent and reliable way of working, outstanding communication skills and team spirit
- You have a high level of commitment, flexibility and strong sense of responsibility
- You must be fluent in English and preferentially in German (not a prerequisite but of advantage)
What we offer
- You will enter an internationally leading working group in cardiac research, pursuing the ambitious goal of developing novel effective cardiac treatment options
- Your work will be an integral and indispensable part of our translational strategies
- You will have the opportunity for independent and team-oriented work in a fruitful atmosphere
- We will promote your personal and professional development and your qualifications in a clinically highly relevant and future-oriented area
- Your salary is based on the TV-L system (salary agreement for public service employees).
- Collectively agreed remuneration, attractive company pension scheme (VBL)
- 30 days vacation
- Sustainable travel: job ticket
- Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
- Wide range of health, prevention and sports offers
Interessiert?
We are looking forward to your application online.
Institut für Experimentelle Kardiologie